Cysteine Proteinase Inhibitors

Human Hydroxysteroid Sulfotransferase SULT2B1: Two Enzymes Encoded by a Single Chromosome 19 Gene

Information Systems / Pharmacology / Genetics / Genomics / Confocal Microscopy / Gene expression / Functional Genomics / Cercopithecus aethiops / Pregnancy / Humans / Mutation / Placenta / Haplotypes / Pharmacogenetics / Female / Animals / Male / Homology / Alternative splicing / Prostate / Enzyme / African Americans / Molecular cloning / Trachea / Substrate Specificity / Isoenzymes / Linkage Disequilibrium / European Continental Ancestry Group / Dehydroepiandrosterone / Amino Acid Profile / Alternative Splicing / Amino Acid Sequence / Base Sequence / Genetic Mapping / Open Reading Frame / Recombinant Proteins / Small Intestine / Cysteine Proteinase Inhibitors / Molecular Sequence Data / Gene expression / Functional Genomics / Cercopithecus aethiops / Pregnancy / Humans / Mutation / Placenta / Haplotypes / Pharmacogenetics / Female / Animals / Male / Homology / Alternative splicing / Prostate / Enzyme / African Americans / Molecular cloning / Trachea / Substrate Specificity / Isoenzymes / Linkage Disequilibrium / European Continental Ancestry Group / Dehydroepiandrosterone / Amino Acid Profile / Alternative Splicing / Amino Acid Sequence / Base Sequence / Genetic Mapping / Open Reading Frame / Recombinant Proteins / Small Intestine / Cysteine Proteinase Inhibitors / Molecular Sequence Data

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S 1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids

Thermodynamics / Kinetics / Humans / Animals / Drug Design / Peptides / Substrate Specificity / Cysteine endopeptidases / Amino Acid Profile / Protozoan Proteins / Recombinant Proteins / Hydrolysis / Biochemistry and cell biology / Cysteine Proteinase Inhibitors / Peptides / Substrate Specificity / Cysteine endopeptidases / Amino Acid Profile / Protozoan Proteins / Recombinant Proteins / Hydrolysis / Biochemistry and cell biology / Cysteine Proteinase Inhibitors

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Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia

Neurochemistry / Apoptosis / Caspases / Ischemia / Animals / Male / Neurons / Phenotype / Rats / Retinal Ganglion Cells / Reperfusion injury / Retinal Diseases / Neurosciences / Interneurons / Ocular Hypertension / Enzyme Induction / Cysteine Proteinase Inhibitors / Male / Neurons / Phenotype / Rats / Retinal Ganglion Cells / Reperfusion injury / Retinal Diseases / Neurosciences / Interneurons / Ocular Hypertension / Enzyme Induction / Cysteine Proteinase Inhibitors

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An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

Organic Chemistry / Malaria / Humans / Drug Resistance / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors

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Antioxidants block proteasome inhibitor function in endometrial carcinoma cells

Vitamins / Apoptosis / Western blotting / Antioxidants / Ubiquitin / Humans / Female / Vitamin E / Caspase / Coumarins / Ascorbic Acid / Boronic Acids / Endometrial carcinoma / Cell Survival / Anti Cancer Drugs / Anti Cancer / Antipyrine / PROTEASOME INHIBITOR / Cysteine Proteinase Inhibitors / Humans / Female / Vitamin E / Caspase / Coumarins / Ascorbic Acid / Boronic Acids / Endometrial carcinoma / Cell Survival / Anti Cancer Drugs / Anti Cancer / Antipyrine / PROTEASOME INHIBITOR / Cysteine Proteinase Inhibitors

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Inhibition of proteasomal proteolysis affects expression of extracellular matrix components and steroidogenesis in porcine oocyte-cumulus complexes

Extracellular Matrix / Animal Production / Progesterone / Protein Turnover / Female / Animals / Real Time / Swine / Veterinary Sciences / Oocytes / Tumor Necrosis Factor–α (TNF) / Trypsin Inhibitor / Ubiquitin proteasome pathway / Cell Adhesion Molecules / PROTEASOME INHIBITOR / Cysteine Proteinase Inhibitors / Animals / Real Time / Swine / Veterinary Sciences / Oocytes / Tumor Necrosis Factor–α (TNF) / Trypsin Inhibitor / Ubiquitin proteasome pathway / Cell Adhesion Molecules / PROTEASOME INHIBITOR / Cysteine Proteinase Inhibitors

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Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid

Organic Chemistry / Apoptosis / Humans / Mice / Animals / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors

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MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity

British / Apoptosis / Caspases / Humans / Liver / Mice / Female / Animals / Male / Brain Ischemia / Caspase / Doxorubicin / Rats / Myocardial Infarction / HeLa cells / Tumor necrosis factor-alpha / Cysteine Proteinase Inhibitors / DNA fragmentation / Cycloheximide / Mice / Female / Animals / Male / Brain Ischemia / Caspase / Doxorubicin / Rats / Myocardial Infarction / HeLa cells / Tumor necrosis factor-alpha / Cysteine Proteinase Inhibitors / DNA fragmentation / Cycloheximide

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Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid

Organic Chemistry / Apoptosis / Humans / Mice / Animals / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors

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S 1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids

Thermodynamics / Kinetics / Humans / Animals / Drug Design / Peptides / Substrate Specificity / Cysteine endopeptidases / Amino Acid Profile / Protozoan Proteins / Recombinant Proteins / Hydrolysis / Biochemistry and cell biology / Cysteine Proteinase Inhibitors / Peptides / Substrate Specificity / Cysteine endopeptidases / Amino Acid Profile / Protozoan Proteins / Recombinant Proteins / Hydrolysis / Biochemistry and cell biology / Cysteine Proteinase Inhibitors

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Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia

Neurochemistry / Apoptosis / Caspases / Ischemia / Animals / Male / Cell Death / Neurons / Phenotype / Caspase / Apoptose / Rats / Rat / Retinal Ganglion Cells / Reperfusion injury / Retinal Diseases / Neurosciences / Interneurons / Ocular Hypertension / Enzyme Induction / Cysteine Proteinase Inhibitors / Male / Cell Death / Neurons / Phenotype / Caspase / Apoptose / Rats / Rat / Retinal Ganglion Cells / Reperfusion injury / Retinal Diseases / Neurosciences / Interneurons / Ocular Hypertension / Enzyme Induction / Cysteine Proteinase Inhibitors

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Design and Synthesis of Endoperoxide Antimalarial Prodrug Models

English / Prodrugs / Drug Design / Chalcones / CHEMICAL SCIENCES / Antimalarials / Cysteine Proteinase Inhibitors / Antimalarials / Cysteine Proteinase Inhibitors

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An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

Organic Chemistry / Malaria / Humans / Drug Resistance / Hybrids / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors

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Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines

Hypoxia / Humans / Male / Cathepsin / Anticancer / Aged / Middle Aged / Oral Squamous Cell Carcinoma (OSCC) / Mouth Neoplasms / cystatin C / cystatin B / Cysteine Proteinase Inhibitors / Hypopharyngeal Neoplasms / Aged / Middle Aged / Oral Squamous Cell Carcinoma (OSCC) / Mouth Neoplasms / cystatin C / cystatin B / Cysteine Proteinase Inhibitors / Hypopharyngeal Neoplasms

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Hypoxia Alters Cathepsin B / Inhibitor Profiles in Oral Carcinoma Cell Lines

Hypoxia / Humans / Male / Cathepsin / Anticancer / Aged / Middle Aged / Oral Squamous Cell Carcinoma (OSCC) / Mouth Neoplasms / cystatin C / cystatin B / Cysteine Proteinase Inhibitors / Hypopharyngeal Neoplasms / Aged / Middle Aged / Oral Squamous Cell Carcinoma (OSCC) / Mouth Neoplasms / cystatin C / cystatin B / Cysteine Proteinase Inhibitors / Hypopharyngeal Neoplasms

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Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia

Neurochemistry / Apoptosis / Caspases / Ischemia / Animals / Male / Cell Death / Neurons / Phenotype / Caspase / Apoptose / Rats / Rat / Retinal Ganglion Cells / Reperfusion injury / Retinal Diseases / Neurosciences / Interneurons / Ocular Hypertension / Enzyme Induction / Cysteine Proteinase Inhibitors / Male / Cell Death / Neurons / Phenotype / Caspase / Apoptose / Rats / Rat / Retinal Ganglion Cells / Reperfusion injury / Retinal Diseases / Neurosciences / Interneurons / Ocular Hypertension / Enzyme Induction / Cysteine Proteinase Inhibitors

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